The overall objective is to generate new knwoledge and technologies for improved diagnosis and control of Human African Trypanosomiasis (HAT) and Leishmaniasis (LEI).
The specific objectives are:
1.- To develop and validate low-tech molecular tests for laboratory diagnosis and (sub-) species differentiation in LEI and HAT.
2.- To develop and validate a sensitive point-of-care test for differential molecular LEI and HAT diagnosis based on ribosomal RNA (rRNA) detection.
3.- To strengthen research capacity of African investigators and research institutes on the biology and diagnosis of HAT and LEI.
1. Project management and technology transfer
2. Parasite cryobank
3. Study of polymorphism within the diagnostic target sequences.
4. Standard protocols for sampling, preparation and storage bioclinical material.
5. Clinical sample cryobank.
6. Development and proof-of-principle of AMP-OC-DIAG/IDEN test
7. Laboratory evaluation (Phase II) of AMP-OC-DIAG/IDEN
8. Development and proof-of-principle of HYB-OC-DIAG
9. Laboratory (Phase II) evaluation of HYB-OC-DIAG
10. Field evaluation of HYB-OC-DIAG
11. Commercial evaluation of the developed tests (Phase IV).
Leishmaniasis, Trypanosomiasis, Molecular diagnostic techniques
|Parasite Diagnosis Unit||member||2005-11-01||2009-10-01|
created:2011-12-14 14:18:59 UTC, source:web