Epidemiology of eye-spot, Septoria leaf blight, powdery mildew, rusts and Fusarium head blight on winter wheat. Management and improvement of the web-site "Proculture" , an interactive decision support system for early fungicide protection against Mycosphaerella graminicola, integrating meteorological and crop data, plant growth and disease development models with occasional field inspections. Adaptation of this tool to wheat growing conditions of Grand-Duché de Luxembourg. Effect of the reduction of the number of applications by the above tool as well/or by the use of reduced doses on protection duration against the various fungal infections, notably the mycotoxin producing head blight Fusarium, and on fungicide resistance selection. Modulation of the decision according to cultivar and fertilisation.