The National Botanic Garden of Belgium detains living plant collections of more than 25.000 accessions from 17.000 taxa or 14.000 species. This material is cultivated for research, conservation and educational purposes. In order to increase the efficiency of its management and to respond to the ever increasing demands for information, a computerized data is being developed. The software used is PROGRESS, a fourth generation relational database management system. The structure allows to avoid redundancy and to assure the integrity of the information. Programmes are developed with a multi-user-friendly approach. The database is organized into some 53 files and 240 descriptors concerning identification, synonymy, source, origin, cultivation, seed production and distribution, herbarium specimens, photography, plant observations, ... It currently includes data on 41.000 accessions and 31.000 taxa.